Download e-book for iPad: Adjuvant Therapy of Primary Breast Cancer VI by E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn,

By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)

ISBN-10: 3540640851

ISBN-13: 9783540640851

ISBN-10: 364245769X

ISBN-13: 9783642457692

ISBN-10: 3642457711

ISBN-13: 9783642457715

This quantity offers an updated survey of present laboratory and, in general, medical learn at the diagnostic and remedies in basic breast melanoma. The chapters derive from the invited professional lectures awarded on the sixth foreign convention on basic Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma group has been eagerly expecting this quantity and its consensus platform and proposals. there is not any substitute to this assembly and e-book within the box of adjuvant remedy of fundamental breast cancer.

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Additional resources for Adjuvant Therapy of Primary Breast Cancer VI

Example text

Prevention trials using clinical endpoints are always subject to high costs. Also, the risk of unexpected detrimental effects has recently been highlighted, and much emphasis has been put on the search for intermediate, surrogate endpoints. Surrogate endpoints are biological markers that may be assessed or observed prior to the clinical appearance of the disease, bearing some relationship to the deVelopment of that disease. They are referred to as Estrogen/Hormone Replacement Therapy and the Etiology of Breast Cancer K.

1995). Interventional studies of the use of ERT in postmenopausal women have also been carried out. A study, published in the New England Journal of Medicine (NEJM), showed that estrogen use begun shortly after menopause resulted in a reduction of fractures by 50% (Weiss et al. 1980). Additional studies have now shown that estrogen can be associated with this effect even when it is begun in women with established osteoporosis and a median age of over 65 years (Lufkin et al. 1992). In all studies the effect of ERTIHRT seems confined to current users.

Arch Intern Med 156:2213-2217 PEPI Trial (1995) Effects of estrogen or estrogen/progestin regimes on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial. JAMA 273:199-208 Pike MC, Peters RK, Cozen W, Probst-Hensch NM (1997) Estrogen-progestin replacement therapy and endometrial cancer. J Nat! Cancer Inst 89:1110-1116 Psaty BM, Heckbert SR, Atkins D, Lemaitre R, Koepsell TD, Wahl PW, Siscovick DS, Wagner EH (1994) The risk of myocardial infarction associated with the combined use of estrogen and progestins in postmenopausal women.

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Adjuvant Therapy of Primary Breast Cancer VI by E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)

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