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By I. H. Stevenson (auth.), G. Barbagallo-Sangiorgi, A. N. Exton-Smith (eds.)

ISBN-10: 1461297214

ISBN-13: 9781461297215

ISBN-10: 1461327911

ISBN-13: 9781461327912

One of the best advances in Geriatric drugs over the past area of a century has been the elevated awareness of the probabilities of remedy for aged sufferers. overlook has been changed by way of a extra positive healing endeavour and numerous previous humans have benefitted from this strategy. yet there's additionally a disadvantage, and this is often the chance of damaging uncomfortable side effects of drugs that are frequently without delay proportional to the organic efficiency of the drug and should be unpredictably elevated as a result of adjustments within the senile organism. in truth the anatomical and organic adjustments in outdated age modify either the kinetics of such a lot medications and the receptor reaction. as a result of those alterations the person tolerance of elderly sufferers to drug remedy will be really diverse from that of more youthful topics. hence for various purposes aged sufferers obtain extra medications, yet they're at the next possibility of encountering adversarial reactions, which regularly exhibit peculiar scientific good points. we will accordingly converse of "geriatric iatrogenic problems" and indicate that a few of these unwanted effects are decided via a fancy pathogenesis as a result specific pathophysiological situation within the aged. you will need to inspire the behavior of individ­ ually comparing power possibility as opposed to anticipated merits of gear based on an analogous rules followed within the overview of cost/benefit ratio.

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F. Spano, and M. Trabucchi, Dopamine receptor sensitivity in brain and retina of rats during aging, Brain Res. 138:565 (1977). M. H. Makman, H. S. Ahn, L. J. Tha1, N. S. Sharpless, B. Dvorkin, S. G. Horowitz, and M. 192:177 (1980). J. K. Marquis, A-S. Lippa, and R. W. Pharmaco1. 30:1876 (1981). J. E. Heusner, and H. B. Bosmann, GABA stimulation of 3 H_ diazepam binding in aged mice, Life Sci. 29:971 (1981). M. Memo, P. F. Spano, and M. Trabucchi, Brain benzodiazepine receptor changes during ageing, J.

But it is also true for other organs, due to the deterioration of enzyme &ystems, and the reduction and/or alteration of receptors. Assessment of drug sensitivity constitutes a major problem, as there is a lack of reliable methods to determine the target organ response. In fact, homeostatic mechanisms are impaired in thermoregulation, glucose homeostasis,coordination of motor function, and postural hypotension. All these variables complicate the investigation of drug effect, and need to be constantly taken into account.

Clin. 3:157 (1981). G. Barbagallo Sangiorgi, A. Di Sciacca, G. Frada Jr, R. Malta, C. Geront. 29:391 (1981). G. Barbagallo Sangiorgi, A. Di Sciacca, A. Pardo, Potassium depletion in aged patients; an evaluation through red-bloodcell potassium determination, Age & Ageing 8:190 (1979). 40 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. G. B. SANGIORGI G. J. Caranasos, R. B. Stewart, L. E. Ass. 228:713 (1974). C. M. Castleden, C. F. Pharmacol. 7:49 (1979). K. A. Conrad, R. ,"Drug Therapy for the Edlerly," C.

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Aging and Drug Therapy by I. H. Stevenson (auth.), G. Barbagallo-Sangiorgi, A. N. Exton-Smith (eds.)

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